日本細菌学会でハスカップ研究発表

【第98回日本細菌学会総会】

で

ハスカップ研究発表を致します

「会場」

石川県立音楽堂

〒920-0856 石川県金沢市昭和町２０−１

「期間」

5月29日〜31日

【Japanese Society for Bacteriology】

P2-025

Changes in gut microbiota in allergic mice treated with Lonicera caerulea extract

○南 正明1，中村 峰夫2（1名市大院・医・細菌，2中村薬局）○Masaaki Minami1, Mineo Nakamura2 (1Dept. Bacteriol. Nagoya City Univ. Grad. Sch. Med., 2Nakamura Pharm.)

In recent years, it has become clear that the diversity of gut microbiota is closely related to the onset and severity of allergic diseases. Lonicera caerulea fruit (LCF) is rich in functional components such as polyphenols. In this study, we investigated the effects of LCF extract on the gut microbiota of BALB/c mice, especially in an allergic disease model. Six-week-old female BALB/c mice were divided into four groups: a control group, an LCF extractadministered group, an OVA-sensitized group, and an OVA-sensitized + LCF extract-administered group. Each group was orally administered raw food or LCF extract. After 14 days, feces were collected aseptically from each mouse, DNA was extracted, and the 16S rRNA gene region was analyzed using a next-generation sequencer. In the LCF extract-administered group, the proportion of the Firmicutes phylum was significantly decreased and the proportion of the Bacteroidetes phylum tended to be significantly increased compared to the untreated group. A similar tendency was observed in the OVA-sensitized mice. However, in the OVA-sensitized +LCF extract-administered group, the proportion of Firmicutes increased and the proportion of Bacteroidetes decreased. We suggest that LCF extract significantly changes the composition of the intestinal microbiota of mice, especially in allergy model mice.

https://aeplan.jp/jsb2025/